Proton Pump Inhibitors And Their Effective Use
Side effects
On the part of the digestive tract: indigestion, nausea, diarrhea, constipation, abdominal pain, flatulence, dry mouth, lack of appetite;
From the nervous system: headache, dizziness, fatigue (including muscle), sleep disturbance, drowsiness, depression, anxiety, restlessness, excitation, hallucinations;
From other organs and systems: an allergic reaction (bronchospasm, pharyngitis, rhinitis, skin rashes, itching), myalgia, arthralgia.
In short (up to 3 months) of therapy, proton pump inhibitors side effects occur rarely. With long-term (especially in a few years) is continuously receiving these indian drugs in patients gipergastrinemiya occurs, the phenomenon of progressive atrophic gastritis may develop Uzelkov hyperplasia of endocrine cells (ECL-cells) of gastric mucosa, producing histamine.
Gipergastrinemiya most pronounced when using rabeprazole. 2-3 weeks after cessation of treatment in serum gastrin level returned to the original. If necessary, prolonged or continuous maintenance treatment to reduce the severity gipergastrinemii proton pump inhibitors is recommended to take along with the synthetic prostaglandin analog (misoprostol) or Pirenzepine, which significantly reduces the level of gastrin.
Application of proton pump inhibitors also leads to increased levels of pepsinogen I in serum. Gipergastrinemiya and raising pepsinogen I in the treatment of these drugs is much more pronounced in patients infected with Helicobacter pylori, compared to patients who have been held its eradication.
Admission omeprazole 40 mg daily led to a decrease in motor-evacuation function of the stomach. After a 10-day course of treatment there were differences in the concentrations motilina, gastrin and cholecystokinin in the blood serum in the groups who received omeprazole and placebo. Reducing motor-evacuation function of the stomach due gipomotilinemii during treatment with proton pump inhibitors, is probably one of the causes of gastroesophageal reflux disease after eradication therapy.
Interactions with other pharmacological agents:
Pharmacokinetic
You can change the pH-dependent absorption of generics belonging to the groups of weak acids (slowdown) and bases (acceleration).
Dosage regimen
Inside: the morning, before eating.No chewing. Squeezed a small amount of water.
Intravenous: once a day.
Application of proton pump inhibitors in elderly patients do not require dose adjustment.Since proton pump inhibitors are characterized by slow onset of action (not earlier than 1 h), they are not suitable for treatment on demand (at the time of pain, heartburn). For such therapy appropriate to apply modern Antacids drugs, or soluble tablet H-2 blockers (the effect appears within 1.6 minutes).
Product
The product is available in dosage form having acid-shell, which dissolves in the intestines.
Precautions
Be used with caution in children and elderly patients. Treatment of patients with reduced liver function should begin with half-doses, gradually increasing them to the recommended. Should regularly check the activity of liver enzymes, if they increase the generic should be discontinued. Before and after therapy is required endoscopic control to exclude malignancies, as lanzoprazol may mask symptoms and delay the establishment of an accurate diagnosis. Should abandon breast-feeding during treatment. The following article was published by a Online Pharmacy Without Prescription.
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